Science Fair Project Encyclopedia
It is a serine protease that is released as plasminogen into the circulation and activated by tissue plasminogen activator (tPA), thrombin, fibrin and factor XII (Hageman factor). It is inactived by alpha 2-antiplasmin, a serine protease inhibitor (serpin).
Apart from fibrinolysis, plasmin proteolyses proteins in various other systems: it activates collagenases , some mediators of the complement system and weakens the wall of the Graafian follicle (leading to ovulation). It cleaves fibrin, fibronectin, thrombospondin , laminin and von Willebrand factor.
Deficiency in plasmin may lead to thrombosis, as clots are not degraded adequately.
The contents of this article is licensed from www.wikipedia.org under the GNU Free Documentation License. Click here to see the transparent copy and copyright details