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Inhibin contains an alpha and beta subunit linked by disulfide bonds. Two forms of inhibin differ in their beta subunits (A or B), while their alpha subunits are identical. Inhibin belongs to the transforming growth factor-β (TGF-β) family.
FSH stimulates the secretion of inhibin from the granulosa cells of the ovary. In turn, inhibin suppresses FSH. Inhibin secretion is diminished by GnRH, and enhanced by insulin-like growth factor-I. Inhibin B reaches a peak in the early-mid follicular phase, and a second peak at ovulation, in contrast to inhibin A that reaches its peak in the midluteal phase. Inhibin is produced in the gonads, pituitary gland, placenta and other organs.
Activin is a related peptide that counteracts inhibin.
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