Angelica Singleton Van Buren (February 13,1818 – December 29,1877) was the daughter-in-law of 8th United States President Martin Van Buren. She was married to the President's son, Abraham. She assumed the post of first lady because the president's wife had died 19 years earlier. Although Martin was rumored to have flirtations, he remained unwed through out the rest of his life.

Raised in high society and related by marriage to Dolley Madison, Angelica brought the air of sophistication to her role of acting first lady. Married in 1838, the couple took an extended trip through Europe; when they returned in 1839, she undertook the duties of White House hostess for the rest of Martin Van Buren's presidency. After Martin was defeated for re-election in 1841, Angelica and her husband lived at the Van Buren home in Kinderhook, Lindenwald, and wintered at her family home in South Carolina. From 1848 until her death at age 59, she lived in New York City.